Leaders visit St. John's
Football - Canada Life Premier League leaders St. Mary's hope to make it six wins from six played when they travel to St. John's.
The home side will be confident after a 4-2 success over Rushen in midweek.
Champions St. George's have won their opening four fixtures and make the trip up the east coast to Laxey who are unbeaten at home.
Elsewhere, Peel play Ayre, Corinthians go to Rushen, Old Boys tackle Colby and Ramsey host Union Mills.