Division Two leaders at home to Douglas Athletic
Division Two leaders Colby welcome Premier League opposition to the south of the Island in the first round of the ECAP FA Cup.
Douglas Athletic are the visitors to Station Fields where home striker Carl Hickey has been in great form with 32 goals to his name so far this season.
Holders Peel, who are in a good run of form, travel to second tier Onchan.
Premier leaders St Mary's are also on the road as they head to promotion-chasing Ayre.
Rushen have a trip to Billygoat Park to face Foxdale.
Douglas Royal against Malew at Ballafletcher has been postponed as the southerners can't field a team - Royal go through to the next round.
There are two all top flight fixtures with Ramsey playing Old Boys and St Georges at home to Pulrose.